This is way cooler than Guitar Hero

UrbanGuitar.com :: Main Stage :: Guitarmed and Dangerous

New Yorkers David Hindman and Evan Drummond have created a new form of gaming, and the guitar- a real one- is the controller. Conceived and developed while Hindman was a student at New York University, “Modal Kombat” is an extension of the classic game Mortal Kombat. Instead of battling with buttons, however, characters fight by responding to notes, chords, and melodies played live by participants on guitar. The resulting performance is “a modern-day ‘dueling banjos,’” says Hindman.

There’s some video of it on the modalkombat.com site.